L-alpha Glycero-phospho-choline (GPC) is a naturally occurring phospholipid precursor and metabolite derived from phosphatidylcholine. It is the most effective nutrient to increase blood choline levels, thus to provide the precursor for acetylcholine – a neurotransmitter – synthesis, which improves vitality and recovery after extensive exercise.

Alpha-GPC:A Building Block Of Acetylcholine (AC)

After oral administration, Alpha-GPC is converted to phosphorylcholine, which is a metabolically active form of choline.Phosphorylcholine migrates to the synaptic nerve endings found throughout the entire central nervous system, and in turn increases acetylcholine synthesis and release. Acetylcholine (AC) is a vastly important neurotransmitter present in both brain and muscle tissue.In the brain AC plays a key roll in basically every cognitive function, while in muscle it is vitally involved in muscle contraction, as it is the major neuro-transmitter involved in regulating physiological response to exercise.

Acetylcholine (AC) And Improved Muscular Performance

Starting in the spinal cord, motor neurons branch along their axons and come in contact with muscle fibers at their motor units, where AC is called upon to deliver the action potential to each muscle fiber at the motor end plate, thus initiating muscle contraction.Motor units are recruited in order of their size (Size Principle), starting with the smallest in size and weakest in degree of tension they can generate.According to this principle, the recruitment sequence begins with Type I motor units (slow twitch, fatigue-resistant, highly oxidative), progresses to Type IIa motor units (fast twitch, fatigue-resistant, oxidative and glycolytic), and finally to Type IIb motor units (fast twitch, fatigable, glycolytic).

It has been demonstrated through scientific study, that engaging in intense exercise can cause a significant reduction in plasma choline levels, thus reducing global stores of AC, and causing a negative impact on endurance and muscular performance.From a physiological standpoint, this is best explained by the fact that the diminishment of AC substantially compromises the continual firing of motor units and contraction of “movement specific” muscle groups.

It can be hypothesized that since all muscle movements – explosive power output, agility, jumping ability – are related to contraction, and contraction is related to available AC stores, then maximizing AC should optimize every type of muscular performance.

AlphaSize® A-GPC has been shown to naturally and significantly increase the level of AC, and thus offers a unique means to enhance and optimize athletic performance.When combining the acknowledged mental performance boosting effects with the muscular performance gaining effects, AlphaSize® A-GPC can be viewed as a very novel, safe, and natural nutraceutical, with significant performance enhancing capabilities.Since most athletic endeavors demand superior mental clarity as well as muscular strength, agility, and finesse, AlphaSize® A-GPC is the hottest nutraceutical in the“mind to muscle” category, and is worthy of consideration in novel formulations.AlphaSize® A-GPC has particular application in sports nutrition supplements, targeted to individuals concerned with top performance and youthful body compositions.

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